Koenigboje1025

These findings further validate the utility of targeting myeloid NF-κB p50 as a strategy for cancer therapy and demonstrate activity of p50-IMC generated by gene editing of syngeneic marrow cells, a cell product relevant to clinical translation.

Vignette research on binge-eating disorder (BED) stigma is limited and lacking methodological rigor. Existing studies lack control vignettes and typically present characters with overweight or obesity, introducing the confound of weight stigma. This study examined BED stigma while addressing these limitations.

Participants (N = 421) were assigned to read one of six vignettes describing a woman with either BED or no BED as well as either no mention of weight, a recommended weight, or an obese weight. Four questionnaires examined personality stereotypes, emotional reactions to the character, desire for social distance from the character, and blame attributions.

The character with BED was ascribed more negative personality characteristics and faced less positive emotional reactions than the character without BED, regardless of weight status. However, BED stigma did not emerge for social distance or blame attributions. Regarding weight stigma, evidence was limited and moderated by the presence of BED, sugge campaigns as well as policy and public health initiatives.

Smoking is considered a risk factor for periodontitis genesis and progression. Numerous clinical studies have demonstrated the negative effect of smoking, in particular the number of cigarettes consumed (NCC), on periodontal clinical parameters. However, smoking addiction assessed by the Fagerström test for nicotine dependence (FTND) has received little attention in periodontal research.

In smoking patients presenting with periodontitis, the periodontal clinical features were measured and correlated with smoking status. The ability of FTND and NCC to predict periodontitis severity was assessed and compared.

Thirty-four smoking patients aged 46.5 ± 11.5 years were included. The means of NCC and FTND were 16.6 ± 5.5 and 5.2 ±1.8, respectively. NCC and FTND were correlated with each other (r=0.57, P<0.001). Patients had stage III (44.1%) or stage IV (55.9%) periodontitis and 73.5% presented a generalized extension of periodontitis. The combination of FTND and NCC in discerning disease severity (ROC curve analysis AUC=0.746, P=0.027) was superior to each indicator separately. selleckchem A discriminant score based on both indicators (D=-0.42 - 0.15 × NCC + 0.63 × FTND) derived by logistic regression showed the opposite role of the indicators and the greater relevance of FTND (P=0.031) compared to NCC (P=0.084) in the relationship.

This study shows that FTND could substantially complement NCC as an indicator of smoking status in periodontal research.

This study shows that FTND could substantially complement NCC as an indicator of smoking status in periodontal research.Sabine Bognar and Manuel van Gemmeren from the WWU Münster have been invited to contribute the cover of this issue. The image depicts a volcano to symbolize the general theme of sulfur chemistry, whereas the piles of rubble reflect the selectivity of the reaction. Read the full text of the article at 10.1002/chem.202004835.DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism. As we review here, current structural approaches have revealed unprecedented insights into the complex DNA-topoisomerase interaction and strand passage mechanism, helping to advance our understanding of their activities in vivo. This has been complemented by single-molecule techniques, which have facilitated the detailed dissection of the various topoisomerase reactions. Recent work has also revealed the importance of topoisomerase interactions with accessory proteins and other DNA-associated proteins, supporting the idea that they often function as part of multi-enzyme assemblies in vivo. In addition, novel topoisomerases have been identified and explored, such as topo VIII and Mini-A. These new findings are advancing our understanding of DNA-related processes and the vital functions topos fulfil, demonstrating their indispensability in virtually every aspect of DNA metabolism.Creative solutions to manage stormwater include ecologically based designs, such as biofilter structures. A laboratory experiment was established to study the ability of biofilters to remove nutrients, metals, total suspended solids (TSS), and total organic C originating from roadside stormwater as melted snow. Special attention was paid to the removal of P. In addition, the fate of microplastics (MPs) in the biofilters was followed. The materials selected for biofilters were (a) crushed light-expanded clay aggregates without biochar or amended with biochar, (b) Filtralite P clay aggregates, (c) crushed concrete, or (d) filter sand. A layer to support grass growth was placed above these materials. Stormwater was rich in TSS with associated P and metals, which were substantially retained by all biofilters. Filtralite and concrete had almost 100% P removal, but the high pH had adverse effects on plants. Light-expanded clay aggregates had lower retention of P, and, when mixed with biochar (30% v/v), the leaching of P increased and N retention was improved. None of the materials was ideal for treating both nutrients and metals, but sand was generally best. Vegetation improved N retention and stormwater infiltration. Plant roots formed preferential pathways for water and associated substances, evidenced by the accumulation of MPs along root channels. No MPs were found in discharge. Given the high loading of suspended solids and associated contaminants in snowmelt from traffic areas and their efficient retention in biofiltration, results of this study suggest the implementation of such stormwater management solutions along road verges.Continuous capture with affinity chromatography is one of the most important units for continuous manufacturing of monoclonal antibody (mAb). Due to the complexity of three-column periodic counter-current chromatography (3C-PCC), three approaches (experimental, model-based, and simplified approaches) were studied for process development and optimization. The effects of residence time for interconnected load (RTC ), breakthrough percentage of the first column for interconnected load (s) and feed protein concentration (c0 ) on productivity and capacity utilization were focused. The model-based approach was found superior to the experimental approach in process optimization and evaluation. Two phases of productivity were observed and the optimal RTC for the maximum productivity was located at the boundary of the two phases. The comprehensive effects of the operating parameters (RTC , s, and c0 ) were evaluated by the model-based approach, and the operation space was predicted. The best performance of 34.5 g/L/h productivity and 97.